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Drug burden and functional outcomes in nursing home patients with Dementia
8th International Conference on Dementia and Dementia Care
Lianne M J Sanders
University of Groningen, Netherlands
Posters & Accepted Abstracts: J Alzheimers Dis Parkinsonism
Abstract
Purpose: The Drug Burden Index (DBI) is a tool to quantify the anticholinergic and sedative load of drugs. Establishing functional correlates of the DBI could optimize drug prescribing in patients with dementia. In this cross-sectional study, we determined the relationship between DBI and cognitive and physical function in a sample of patients with dementia. Methods: Using performance-based tests, we measured physical and cognitive function in 140 nursing home patients aged over 70 with all-cause dementia. We also determined anticholinergic (AChDBI) and sedative (SDBI) drug burden separately and in combination as total drug burden (TDB). Results: Nearly one half of patients (48%) used at least one DBI-contributing drug. In 33% of the patients, drug burden was moderate (0Biography
Lianne M J Sanders is an clinical neuropsychologist who currently does a PhD on the effects of exercise in patients with dementia. The aim of her PhD project ‘Train the Sedentary Brain’ (Deltaplan Dementia, ZonMW: Memorabel) is to delay the progression of dementia with a combined aerobic and strength exercise program. Within this project, we investigate the dose-response relationship between exercise and cognition, and possible moderating effects of ApoE4 carriership on exercise effects, in a sample of patients with mild-to-moderate dementia.
