Journal of Analytical & Bioanalytical Techniques
Open Access

Abstract

A large number of transition metal complexes have been used as cleavage agents of DNA and also for novel potential DNAtargeted antitumor drugs. This is essential for further expected applications in many areas like biological gene regulators or cancer chemotherapeutic agents. The identification of metal complex�DNA interaction is of fundamental importance to understanding the molecular basis of therapeutic activity. Metal complexes are well known to accelerate the drug action and the efficiency of a therapeutic agent can often be enhanced upon coordination with metal ions. The pharmacological activity has also been found to be highly dependent on the nature of the metal ion and the donor sequence of the ligands, as different ligands exhibit different biological properties. In the present work a new Co (III) complexes of mixed ligands, 1, 10-phenenthroline (phen) and hydroxamic acid (L1 = AHA (acetohydroxamic acid), and L2 = BHA (benzohydroxamic acid) were synthesised and characterized by NMR, IR, UV-visible and elemental analysis. In the complexes, [Co(phen)2Ln] (Ln = L1, L2), the metal ion is coordinated by six atoms, two oxygen atom from hydroxamic acid and 4N atom from co-ligand 1, 10-phenenthroline to form octahedral Co(III) complexes. The interaction of these complexes with calf thymus DNA has been investigated by absorption spectroscopy and fluorescence spectroscopy.

Biography

Email: chakrabarty_deb@yahoo.com