Journal of Biotechnology & Biomaterials
Open Access

Abstract

Effective medical care is directly related with rapid diagnostics in order to give treatments in minimum time to prevent disease transmission, reducing healthcare costs and improving patient life. What is advisable in the developed world is absolutely necessary in developing countries. The current rapid diagnostic tests for HIV, malaria, dengue, tuberculosis...are developed for use in an overgrown society. In contrast, in the third world, there is not a guaranteed power supply or no means to purchase diagnostic kits or drugs, neither trained personnel. Under these conditions, there is a great chance to spread diseases, until being epidemics. Understanding the real need for diagnostic tools in infectious disease prevention, a sensitive, selective, rapid (<30 min), portable, low-cost (0.5 ?/disk), and integrated multi-analyte; our group has developed a biosensing system based on compact disk technology with features which makes it very useful for low-income settings. The principle of the assay is based on the immobilization of specific receptors on disks, in a microarray format, in order to identify the disease biomarkers in blood. Each positive assay generates an insoluble reaction product which made a change in the reflective properties of the disk. The disk drive quantifies this interference and correlates them well with the concentration of the bioreaction product, resulting in quantitative measurements.

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