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Differential regional fatty acid distribution in normotensive and preeclampsia placenta
6th World Congress on Biotechnology
Alka Rani, Preeti Chavan-Gautam, Savita Mehendale, Girija Wagh and Sadhana Joshi
Bharati Vidyapeeth Deemed University, India
ScientificTracks Abstracts: J Biotechnol Biomater
Abstract
Background: Long chain polyunsaturated fatty acids (LCPUFA) are biologically active fatty acids which regulate placental angiogenesis, inflammation and oxidative stress. Abnormalities in these aspects have been associated with preeclampsia (PE). Further, placenta has a heterogeneous structure with differential vascularization across different regions. We therefore hypothesize that the distribution of fatty acids in various regions of the placenta is altered in PE leading to poor fetal outcome. Methods: In this cross-sectional study we recruited 69 normotensive control (NC) and 44 women with PE. PE women were further classified as those delivered preterm (PTPE, n=24) and at term (TPE, n=20). Fatty acid levels were analyzed from placental samples from four different regions (CF-central fetal, PF-peripheral fetal, CM-central maternal and PM-peripheral maternal). Results: In the NC placenta, AA levels were lower (p<0.05) in CM as compared with CF region. However, such differences were not seen in the TPE and PTPE. In contrast, the DHA levels varied between regions only in the PTPE placenta. Between groups, DHA levels were lower (p<0.05 for both) in the CM and CF regions of the PTPE as compared with NC. The levels of DHA in TPE placenta were similar to NC. AA levels were lower (p<0.05 for both) in CF region of TPE and PF region of PTPE placenta than NC. Conclusions: There is differential pattern of LCPUFA distribution across various regions of the NC, TPE and PTPE placenta. This may have implications for placental growth and development as well as transfer of LCPUFA to the fetus.Biography
Alka Rani is currently pursuing her PhD from IRSHA, Bharati Vidyapeeth Deemed University, India. She has a background of Engineering in Biotechnology as a Gold Medalist. She was awarded INSPIRE Fellowship by DST for pursing her PhD. Her work is published and under revision in many international journals. She has also contributed a chapter in a book of CRC publication.
Email: alkarani01@gmail.com
