Spanish 
Chinese 
Russian 
German 
French 
Japanese 
Portuguese 
Hindi Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers
Google Scholar citation report
Citations : 4334
Journal of Alzheimers Disease & Parkinsonism received 4334 citations as per Google Scholar report
Journal of Alzheimers Disease & Parkinsonism peer review process verified at publons
Indexed In
- Index Copernicus
- Google Scholar
- Sherpa Romeo
- Open J Gate
- Genamics JournalSeek
- Academic Keys
- JournalTOCs
- China National Knowledge Infrastructure (CNKI)
- Electronic Journals Library
- RefSeek
- Hamdard University
- EBSCO A-Z
- OCLC- WorldCat
- SWB online catalog
- Virtual Library of Biology (vifabio)
- Publons
- Geneva Foundation for Medical Education and Research
- Euro Pub
- ICMJE
Useful Links
Recommended Journals
Related Subjects
Share This Page
Differences in vulnerability of neurons and astrocytes to hemeoxygenase-1 modulation: Implications for mitochondrial ferritin
2nd International Conference on Parkinson’s Disease & Movement Disorders
Junxia Xie, Xiaojun Yu, Ning Song and Jun Wang
Qingdao University, China
Posters & Accepted Abstracts: J Alzheimers Dis Parkinsonism
Abstract
Induction of the antioxidant enzyme hemeoxygenase-1 (HO-1) was observed in both astrocytes and neurons in the substantianigra of patients with Parkinsonâ��s disease (PD). In the current study, we investigated whether HO-1 behaves differently between neurons and astrocytes under the condition of neurotoxicity related to PD. The results showed a timedependent HO-1 upregulation in primary cultured ventral mesencephalon (VM) neurons and astrocytes treated with the mitochondria complex I inhibitor 1-methyl-4-phenylpyridinium (MPP+) or recombinant �±-synuclein. However, HO-1 upregulation appeared much later in neurons than in astrocytes. The HO-1 inhibitor zinc protoporphyrin (ZnPP) aggravated MPP+- or �±-synuclein-induced oxidative damage in both astrocytes and neurons, indicating that this HO-1 response was cytoprotective. For neurons, the HO-1 activator cobalt protoporphyrin IX (CoPPIX) exerted protective effects against MPP+ or �±-synuclein during moderate HO-1 upregulation, but it aggravated damage at the peak of the HO-1 response. For astrocytes, CoPPIX always showed protective effects. Higher basal and CoPPIX-induced mitochondrial ferritin (MtFt) levels were detected in astrocytes. Lentivirus-mediated MtFt overexpression rescued the neuronal damage induced by CoPPIX, indicating that a large MtFt buffering capacity contributes to pronounced HO-1 tolerance in astrocytes. Such findings suggest that astrocytetargeted HO-1 interventions have potential as a novel pharmacological treatment strategy in PD.Biography
Junxia Xie is Taishan scholar Distinguished Professor. She is currently the Director of Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders and Excellent Innovative Team of Shandong Province. She is the Vice-President of Qingdao University, Chinese Association of Physiological Sciences as well as Chinese Neuroscience Society. She has 7 projects from the NSFC, including 2 key projects and participates in National 973 Project. She has published 150 articles up to now.
Email: jxiaxie@public.qd.sd.cn
