Clinical Pharmacology & Biopharmaceutics
Open Access

Abstract

Introduction: Familial mediterrean fever (FMF) is an autosomal recessive disease characterized by recurrent self limiting attacks of fever, serositis ( like peritonitis, arthritis, pleuritis) and eryzipelas-like skin lesion. The disease is common among Turks, Armenians, Arabs and non askanazy Jews. FMF may cause amyloidosis which affects the kidneys but may also be accumulated in other organs such as the heart, gastrointestinal tract, and reproductive organs. Case: 30 years old female patient with a diagnosis of FMF is followed for ten years and using colchicine regularly and no nefropathy and amyloidosis history. Patients had an unknown cause infertility and became pregnant after the fourth in vitro fertilization (IVF). The patients blood pressure was increased at the 36th week of pregnancy and she had taken cesarian section. The patient was considered as preeclampsia and she had 300 mg/day proteinuria. After cesarean blood pressure and the proteinuria was back to normal within two months. Discussion: In the literature search we found only 1 case with FMF during pregnancy and complicated with preeclampsia. The course of disease in female FMF patients during pregnancy is variable. Some patients have an attack free period during pregnancy and still other women may experience attacks with high frequency. Apart from the inconcience and the pain during the attacks there is an additional risk, because peritonitis may lead to uterine contractions with eventual abortions, early labor and delivery. During the pregnancy the onset of hypertension and proteinuria after 20 weeks gestation characterizes preeclampsia, a leading cause of maternal mortality. Preeclampsia has been recognized as a potentially fatal complication of pregnancy for more than a century. It complicates between %3 and % 10 of pregnancies and is responsible for a large partion of maternal and perinatal morbidity and death. Despite extensive research into the causes and pathogenesis of this condition, delivery of the fetus and placenta is still the only effective treatment. Conclusion: FMF may trigger preeclampsia during pregnancy. For us to be cautious in terms of preeclampsia during pregnancy in patients with FMF. Pregnant FMF patients without nephropathy and amyloidosis, should be followed closely for preeclampsia.

Biography

Email: drozkanonal@selcuk.edu.tr