Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
Motivational salience-coding dopamine (DA) neurons, being excited by both rewarding and aversive events
with weaker responses to neutral events, offer a suitable instructive signal for neural circuits to learn to
detect, predict, and respond to situations of high importance. In this regard, DA neurons play a crucial role
in motivating efforts to attain high-value goals and in translating awareness of task demands into consistent
motor performance. In the ventromedial substantia nigra pars compacta (SNc) and ventral tegmental area
(VTA), signals are sent to the ventromedial prefrontal cortex and orbitofrontal cortex (OFC), influencing choice
assessment and updating outcome expectations. The nucleus accumbens (NAc) shell receives phasic DA signals
encoding motivational value, while the dorsal striatum processes both motivational value and salience signals.
These signals guide value learning in striatal circuitry, with burst firing facilitating reward learning and pausing
facilitating avoidance learning. Similarly, in the dorsolateral midbrain, DA neurons play a role in coding
motivational salience and project to the dorsal and lateral frontal cortex, impacting cognitive functions such
as attention, working memory, and decision-making. Phasic activation of DA neurons regulates dorsolateral
prefrontal cognitive functions tightly. Moreover, some lateral prefrontal neurons respond to rewarding and
aversive cues, correlating with success in working memory tasks. Salience signals may be directed to the NAc
core, enhancing motivation, cognitive flexibility, and response to reward cues. Understanding these signals
sheds light on how the brain processes motivation and cognitive performance in various contexts. The brain
receives motivational value signals through various sources, including the lateral habenula (LHb) and the
central nucleus of the amygdala (CeA). The LHb, located in the epithalamus, negatively influences DA neurons
and affects learning processes. Conversely, the CeA, within the amygdala, plays a crucial role in orienting,
attention, and motivational responses to rewarding and aversive events. These regions contribute to the intricate
network of motivational signaling in the brain, shaping behavioral responses to environmental stimuli.
Biography
Marziyeh Zarei is a graduate of psychology, neuroscience and human sciences master at the University of Pavia (Italy). Her interests are in neuroscience and cognition. With her passion for this field, Marziyeh hopes to make a significant contribution in the field of cognitive issues in the coming years.
Relevant Topics
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals