Journal of Biotechnology & Biomaterials
Open Access

Abstract

While nanotechnology is providing exponentially new products based on nano-tools, equipment and nanoparticles, the study of their toxicity would be essential. The reduction in size to nano-scale leads to change their surface properties and also increases their chemical activity that causes toxicity. The knowledge of nanoparticles entrance mechanism into the body is useful in evaluation of nanoparticle content into the cell. Here, we are able to answer some of the questions about toxicity. Endocytosis, membrane flows, channels and adherence reactions are some of their entrance mechanisms into the cell. A variety of nanoparticles have different size, shape, surface and chemical composition and they have different toxicity mechanism in the interface with living systems. We will focus on the interaction of nanoparticles with cells, blood and immune system and, finally on when immune system interact with nanoparticles as drug delivery vehicles, resist and take protective reactions. Nanoparticles influence on blood factors too will be discussed. Complement system, blood cells and hemostatic system which are three important parts of blood that are affected by the nanoparticle. We will briefly express the steps of toxicity identification of nanomaterial because it is necessary for identifying their toxicity.

Biography

Email: mtaran@ut.ac.ir