Journal of Biotechnology & Biomaterials
Open Access

Abstract

Stimuli-responsive polymers are special class of polymeric materials which can respond to even very slight changes in temperature, pH, light, and ionic strength, have been widely utilized in tissue engineering, drug delivery systems and sensors. Temperature change is a widely observed phenomenon in the physiological systems. Temperature-sensitive materials have attracted significantly owing their ability of intelligent response to temperature changes. The most challenging aspect in the temperature controlled cell adhesion is the development and design of 3D scaffolds which should provide a suitable and proper environment for easy attachment, proliferation, differentiation and detachment of cells. Poly (N-isopropylacrylamide) (PNIPAM) is a well-known and studied thermo responsive polymer. It exhibits a reversible phase transition between hydrophilicity and hydrophobicity because of intermolecular and intramolecular hydrogen bonding. Based on this mechanism, the poly (N-isopropylacylamide) based matrices could act as the controllable temperature-responsive bio-switches for biomedical and biotechnology applications. On the other hand, conducting polymers especially polyaniline has received much attention in recent past because of good processability, fast charge-discharge and biocompatibility. When fibroblast cells were seeded on the nanofibers surface, the PANI-PNIPAm composite nanofibers exhibited highest cell growth and %live of around 98% indicating very good biocompatibility and possible use of these nanofibers as scaffold for the tissue engineering application recognition.

Biography

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