Journal of Alzheimers Disease & Parkinsonism
Open Access

Abstract

Alzheimer�¢����s disease (AD) is a progressive neurodegenerative disorder pathologically characterized by deposition of I�²-amyloid (A���²) peptides which influenced by oxidative stress and mitochondrial dysfunction. Protein malnutrition increases oxidative damage in cortex, hippocampus and cerebellum. Epigallocatechin-3-gallate (EGCG) has health-promoting effects in CNS, while coenzyme Q10 (CoQ10) is intracellular antioxidant and mitochondrial membrane stabilizer. This study aimed to evaluate the potential protective effects of EGCG and / or CoQ10 against aluminum-induced AD in both normallyfed (NF) and protein malnourished (PM) rats. Both NF and PM groups received daily for four weeks, either saline for control groups or ALCl3 (70mg/kg, IP) for AD induction groups. Treated groups received together with ALCl3, either EGCG (10mg/ kg, IP), CoQ10 (200mg/kg, P.O) or combination of both. Histopathological changes in the brain and biochemical changes in AI�², Acetyl cholinesterase (ACHE) as well as oxidative parameters; (MDA, SOD, TAC) were evaluated for all NF and PM groups. The study revealed that, the progressive brain neurological damage characterizing induction of AD was more pronounced in PM rats. EGCG or CoQ10 has protective effects against brain neural damage accompanied induction of AD as indicated by decreased AI�², ACHE , MDA together with increased SOD , TAC and confirmed by Histopathological examinations in different brain regions. EGCG and CoQ10 combined therapy showed marked protective effects in both NF and PM rats rather than each individual treatment.

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