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P
atients who are seen in clinical practice commonly have multiple problems, yet efficacy data often reflect treatment of a
single illness. Thus, it is useful to know how standard treatment approaches need to be modified for comorbid disorders.
This article briefly describes prevalence, assessment, clinical features, and treatment of comorbid major depression and alcohol
dependence. Comorbid is characterised by symptoms of both depression and anxiety. Patients who have comorbid depression
and anxiety have higher severity of illness, higher chronicity and significantly greater impairment in work functioning,
psychosocial functioning and quality of life than patients only suffering from single disease like depression or anxiety. One of
the most important clinical reasons to screen for comorbidity is that unrecognized depression/anxiety comorbidity is associated
with an increased rate of psychiatric hospitalization and an increased rate of suicide attempts. Sometimes physicians are not
exactly aware of the comorbidity because the symptoms of depression and anxiety are common pathophysiologically. Both major
depression and alcohol dependence carry a significant risk for the development of the other. Severity in one disorder is associated
with severity in the other. Moreover, alcohol dependence prolongs the course of depression, and persistent depression during
abstinence from alcohol is a risk factor for relapse to heavy drinking. Thus, logic dictates that both disorders be identified and
managed concurrently and aggressively. Integrated psychosocial outpatient treatment programs and the ability to treat alcohol
and depression simultaneously have reinforced the need to revisit the traditional management of comorbid major depression and
alcohol dependence more formally
Biography
Souravh Bais has completed his M. Pharmacy at the age of 23 years from RGPV University. He is the Assit. Prof. of Pharmacology, at Rayat College
of Pharmacy, Railmajra, Near Ropar, Nawanshahr-144533, Punjab, India. He has published papers in both national and international reputed
journals.
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