Journal of Bioremediation & Biodegradation
Open Access

Abstract

Introduction: Diabetes Mellitus in developed countries have a prevalence of 11%. Diabetic foot is a complication of diabetes mellitus. The presence of diabetic foot ulcers varies between 4% and 10%. Foot infections are most common cause of hospitalization and often precede amputation. The indicated debridement in almost all ulcers is recommended to maintain a �?¢�?�?�?�?moist wound healing�?¢�?�?�?, using the appropriate dressing. Aim: Aim of the study is to evaluate the effectiveness of a calcium alginate dressing with zinc oxide nanoparticles in the treatment of neuropathic diabetic foot ulcers. Materials & Methods: A prospective randomized controlled trial was conducted in 26 patients. The patients were randomized to two groups: group one (n=28) received treatment with calcium alginate dressings with nanoparticles, while the other group two (n=29) received the treatment (without nanoparticles). The dressing change was performed every 48 h. The duration of observations was at the interval of every 10 weeks. Results: After 10 weeks, healing was achieved in 24 (85.7% of n=28) patients in group one under treatment with calcium alginate nanoparticles versus 21 ( 72% of n=29) in the other group two (calcium alginate without nanoparticles) (p=0.03). The mean time to healing was 36 days�?�?�?±5 in the group one and 42 days�?�?�?±3.4 in group two (p=0.002), with significant differences between the two groups (p<0.028). Conclusion: Most patients included in both groups were not receiving proper treatment of the ulcer, the analysis of the results support the hypothesis that the use of calcium alginate dressings with nanoparticles induces a better tissue regeneration.

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