Journal of Obesity & Weight Loss Therapy
Open Access

Abstract

The aim of the study is to analyze, in the same BMI range, the effectiveness of a circadian nutritional program in subjects with
different body compositions for the fat loss and the maintenance of skeletal muscle mass, and to verify whether the program allows
keeping results in the long run. Data were collected from obese and overweight subjects. Changes over time of body composition
using BIA-ACC (BioTekna, Venice, Italy) medical device, weight, body mass index, dietary habits, physical activity, health status and
lifestyle, were taken into account. Number of subjects: 4120 (1648 males, 2472 females). The subjects were divided into 4 groups
according to percentage of fat mass FM, percentage of skeletal muscle mass and skeletal muscle mass index (SMI). All groups have
adopted a circadian nutritional program for a period of six months as follows: Breakfast, glycemic load (GL): 40 to 60. Snack, GL: 20
to 30. Lunch, GL: 10 to 25. Snack, GL: 2 to 8. Dinner, GL: 0. At the end of the program, changes in weight and body composition were
assessed. The first group showed the greater loss of fat mass and total weight. The groups 3 and 4 obtained fat mass loss and small loss
of muscle mass. The second group showed the lesser loss of fat mass and total weight but with more muscle loss. This study highlights
the importance in evaluating the body composition, and the crucial role of the muscle mass as a fundamental trigger in the metabolic
modulation and regulation of energy expenditure.

Biography

Roberto Gradini is Associate Professor, General Pathology, Sapienza University School of Medicine, Rome, Italy (2001-2015). He is Director, Sapienza University, Rome,
Italy (2007-2015), Visiting Scientist, Anestesiology, La Jolla Universiy, San Diego, USA (2010), Scientific Consultant, Neuroplasticity, University of Lille 1, France (2010-
2011), Visiting Professor, Pathology, Rush University Medical Center, Chicago, USA (2009). He is also a Scientific Consultant, Neuropharmacology, I.N.M. Neuromed,
Pozzilli (2002-2015) and a Clinical Assistant Professor, General Pathology, Loyola University, Chicago, USA (1985-1993).