Journal of Infectious Diseases & Therapy
Open Access

Abstract

Honey has been used throughout the history both as a food and a therapeutic product due to its nutritional value and biological activity (bioactivity) potential. The honeys with high bioactivity are provided to the use of complementary medicine practitioners in developed countries such as USA, UK, Japan, Australia, New Zealand and major EU countries. Wound care in the modern medicine is achieved by using adsorbents, impregnated dressings, foams, hydrogels and hydrocolloids. However, the major problem in wound treatment is the growth of antibiotic-resistant bacteria in the wound area. Meanwhile, honey stands out as the most commonly used agent for wound treatment within the field of traditional and complementary medicine. Both osmotic and high acidity properties of honey, as well as the organic compounds within the nectar sources of honey exert an accelerator effect in the sterilization and healing of the wound. The aim of this study is to examine the healing potential of high bioactivity chestnut honey on the topical burn wounds compared to the control groups in rat model. In this study, rats were induced with burn wounds and divided into 4 groups for treatment, which are saline dressing, honey dressing, Ag sulfadiazine and honey dressing+sherbet. Microscopic analysis of the wound healing was performed through monitoring the skin epithelialization, granulation, neovascularization, inflammation and fibroblast maturation using the immunohistochemical methods. The group treated with honey dressing+sherbet showed the most rapid and effective healing of the burn wound. Based on the findings of this study, the chestnut honey with high bioactivity can be used in clinical trials on burn wounds as a complementary approach to the conventional treatment methods in the future studies.

Biography

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