Journal of Marine Science: Research & Development
Open Access

Abstract

Bacillus flexus S15 isolated from marine soil sample produced 478 mg/l of exopolymeric substances. The colorimetric analysis shows that the exopolymer comprised of about 65% sugars, 3.1% proteins, 0.24 % uronic acids and 12.7% sulphur. FTIR and 1H NMR analysis revealed the presence of functional groups corresponding to carbohydrates, proteins, and sulphate. In differential scanning calorimetric analysis, it was found that the melting temperature (Tm) of exopolymer was 260.45°C. The bacterial exopolymer exhibited cytotoxic activity on A549 cell (IC50 120.36 μg/mL) and antibacterial activity against clinical pathogens. The present study makes a pavement and its possibility for its potential biomedical application.

Biography

R Thirumurugan, Professor has 14 years of teaching and research experience. He obtained his PhD in Aquatic Biotechnology from Bharathidasan University in the year 2000. He had received DST-FAST TRACK Young Scientist award from Department of Science and Technology, Govt. of India. He is pursuing UGC Raman Post Doctoral Fellowship (2014-2015) in Auburn University, USA. He has published more than 30 papers in referred national and international reputed journals. He has been serving as a member in many International Associations and operating various research projects funded by UGC, DST and DAE. He has successfully guided one PhD and 20 MPhil scholars and currently guiding 8 PhD scholars in the area of aquatic biotechnology, marine microbes, nanoscience, probiotics and toxicology.