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Most neuroimaging studies have demonstrated that acupuncture can significantly modulate brain activation patterns in healthy
subjects, although only a few studies have examined clinical pain. In the current study, we combined an experimental acute
low back pain (ALBP) model and functional magnetic resonance imaging (fMRI) to explore the neural mechanisms of acupuncture
analgesia. All ALBP subjects first underwent two resting state fMRI scans at baseline and during a painful episode, and then
underwent two additional fMRI scans, once during acupuncture stimulation (ACUP) and once during tactile stimulation (SHAM)
pseudorandomly, at the BL40 acupoint. Our results showed that compared with the baseline, the pain state had higher regional
homogeneity (ReHo) values in the pain matrix, limbic system, and default mode network and lower ReHo values in the right middle
frontal gyrus, right insula, and right cerebellar tonsil; compared with the OFF status (rest time without acupuncture), ACUP yielded
broad deactivation in ALBP subjects, including nearly all of the limbic system, pain status, and default network, and also evoked
numerous activations in the attentional and somatosensory systems; and compared with SHAM, we found that ACUP induced more
deactivations and fewer activations in the subjects. Multiple brain networks play crucial roles in acupuncture analgesia, suggesting
that ACUP exceeds a somatosensory-guided mind�body therapy for ALBP. To the best of our knowledge, this is the first fMRI study
involving acupuncture for ALBP subjects, and we hope it will help bridge the gap between clinical and experimental pain studies
involving acupuncture treatment.
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