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Blood biomarkers in preclinical Alzheimer Disease
4th International Conference on Vascular Dementia
Howard J Federoff
University of California, USA
Keynote: J Alzheimers Dis Parkinsonism
Abstract
Our group has studied a longitudinal cohort of seniors, >75 yrs, to discover and validate peripheral blood measures that can accurately predict which cognitively normal subjects will progress to amnestic Mild Cognitive Impairment (aMCI) or Alzheimer disease (AD) in a three year period. We initially reported on plasma metabolites which are now more accurate as a diagnostic. We have extended this work on plasma metabolomics and have discovered and validated a panel of 24 analytes that predict phenoconversion to Alzheimer�s disease with accuracy of >96%.Biography
Howard J Federoff over sees the clinical, medical educational, and research missions, as a Vice Chancellor for Health Affairs and CEO of UC Irvine Health. He investigates gene therapy and neurodegenerative diseases. He has published greater than 250 articles and serves on the editorial boards of five journals. He Chaired the NIH Recombinant DNA Advisory Committee and currently Chairs the Gene Therapy Resource Program for NHLBI. He is President of the American Society for Experimental Neurotherapeutics. He received MS, PhD, and MD degrees from the Albert Einstein College of Medicine, did his internship, residency, and clinical and research fellowships at Massachusetts General Hospital/Harvard Medical School. He is a Fellow of the AAAS and National Academy of Inventors.
Email: hjfederoff@gmail.com
