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Biocompatibility of new fiber-reinforced composite materials for craniofacial bone reconstruction
Annual Conference and Expo on Biomaterials
Horatiu Rotaru, Madalina-Anca Lazar, Ioana Baldea, Adina Bianca Bosca, Cristina Prejmerean and Radu Septimiu Campian
Iuliu Hatieganu University of Medicine and Pharmacy, Romania Babes Bolyai University, Romania
ScientificTracks Abstracts: J Biotechnol Biomater
Abstract
This study aims to assess the biocompatibility of new advanced fiber-reinforced composites (FRC) to be used for custommade cranial implants. Four new formulations of FRC were obtained using polymeric matrices (combinations of monomers bisphenol A glycidylmethacrylate (bis-GMA), urethane dimethacrylate (UDMA), triethylene glycol dimethacrylate (TEGDMA), hydroxyethyl methacrylate (HEMA)) and E-glass fibers (300 g/mp). Every FRC contains 65% E-glass and 35% polymeric matrix. Composition of polymeric matrices are: bis-GMA (21%), TEGDMA (14%) for FRC1; bis-GMA (21%), HEMA (14%) for FRC2; bis-GMA (3.5%), UDMA (21%), TEGDMA (10.5%) for FRC3 and bis-GMA (3.5%), UDMA (21%), HEMA (10.5%) for FRC4. Cytotoxicity test was performed on both human dental pulp stem cells and dermal fibroblasts. Viability was assessed by tetrazolium dye colorimetric assay. Subcutaneous implantation test was carried out on forty male Wistar rats, randomly divided into 4 groups, according to the FRC tested. Each group received subcutaneous dorsal implants. After 30 days, intensity of the inflammatory reaction, tissue repair status and presence of the capsule were the main criteria assessed. Both cell populations showed no signs of cytotoxicity following the FRC exposures. Among the FRC formulations, the best results were obtained with FRC3, followed by FRC2. FRC3 showed the mildest inflammatory reaction and this correlated both with the non-cytotoxic behavior and the presence of a well-organized fibrous capsule (Z=-3.16, p=0.002). The composite biomaterials developed may constitute an optimized alternative of the similar materials used for the reconstruction of craniofacial bone defects. According to our studies, we conclude that FRC3 is the best formulation regarding the biological behavior.Biography
Horatiu Rotaru is a young and proficient Maxillofacial Surgeon. He is the Head of the Department of Oral and Maxillofacial Surgery in Cluj-Napoca, Romania. He is qualified as an experienced Researcher in the area of biomaterials, medical imaging and 3D engineered reconstructions. He has particular interest in reconstructive surgery, advanced biomaterials, medical imaging and tissue engineering. He has published more than 45 articles and he is also co-author in 6 books of craniomaxillofacial surgery.
Email: hrotaru@yahoo.com
