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In Association with
Biochemical studies on the effect of turmeric on breast cancer of rats
8th Euro Biotechnology Congress
Soha M Hamdy, Abdel Karim M Abdellatif and Rania M Mahoud
Fayoum University, Egypt
ScientificTracks Abstracts: Biotechnol Biomater
Abstract
Chemoprevention is regarded as one of the most promising and realistic approaches in the prevention of toxic effects of carcinogenic compounds. In this study, we investigated the chemoprevention efficacy of turmeric for 120 days against a single dose of (10 mg/rat) 7, 12-dimethylbenz (a) anthracene (DMBA). 60 rats were divided into four groups, 15 for each: Group I: Control; Group II: Injected with DMBA that induces mammary carcinoma; Group III treated with 5% turmeric before and after injection with DMBA; Group IV treated with 5% turmeric only as Control 2 and the treatments were administered daily for 4 months. At the end of experiment, the animals were sacrificed under anesthesia and their sera were used for evaluation of markers of tumorigenicity (serum levels of Total Sialic Acid (TSA) and carcino-embryonic antigens), markers of endocrine derangement (serum prolactin and estradiol) and markers of oxidative stress (MDA for lipid peroxidation, nitric oxide and total antioxidant). The breast tissues were investigated for malignancy. Results showed statistically significant elevation of Malondialdhyde (MDA), Carcinoembryonic Antigen (CEA), total sialic acid, prolactin, estradiol and nitric oxide and also statistically significant decrease in body weight and total antioxidant in serum of DMBA treated rats as compared with control group but administration of turmeric was associated with decreased levels of tumorigenicity, endocrine derangement and oxidative stress. Histopathological examination revealed the formation of tumor in DMBA-induced rats and these abnormal changes were ameliorated in the rats supplemented with turmeric. In conclusion, these results suggested that supplementation of diet with turmeric provided antioxidant defense with chemopreventive activity against DMBA-induced mammary tumors.Biography
Soha Mohamed Hamdy has completed her PhD in 2001 from Fayoum University. Presently, she is a Professor in Faculty of Science - Chemistry Department at Fayoum University, Egypt.
Email: smh00@fayoum.edu.eg
