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In Association with
Biochemical and histopathological responses of the Swiss albino mice treated with uranyl nitrate
6th World Congress on Biotechnology
Sangeetha Vijayan P
Yenepoya University, India
ScientificTracks Abstracts: J Biotechnol Biomater
Abstract
Uranium is a heavy metal, well known nephrotoxicant and its toxicity varies with dose, time of exposure and form of uranium. The present study shows the kidney damage induced by a single dose of uranyl nitrate at different time intervals; the study also shows recovery of mice after the uranyl nitrate insult. Animals were dosed and sacrificed after 1, 3, 5, 14, 28 days of administration. Maximum tubular damage was showed after 3 days of treatment with uranyl nitrate, it is considered as peak and the biochemical parameters such as BUN and creatinine values were also significantly increased in time and dose dependant manner. Both histopathological and biochemical alterations with respect to control, 1, 3, 5, 14, 28 days of post dosing with uranyl nitrate were evaluated.Biography
Sangeetha Vijayan P has completed her MSc in Biotechnology in 2007 and has research experience of about 5 years. She has worked as Project Fellow in Central Plantation Crop Research Institute (CPCRI), India from 2007-2009. She has also worked as Research Associate in a DBT project “Identification of genes for high productivity in low-light using activation tagging” at Agricultural College Nileshwar, Kasargod (2010). She is currently working as Junior Research Fellow at Yenepoya Medical College, Mangalore from 2012. Her area of interest includes toxicity studies in animal models, genetic diversity studies in plants and molecular biology.
Email: sangidileep@gmail.com
