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Barbatim�£o, a Brazilian wound healing plant, restores markers of senescent human dermal fibroblasts
8th International Conference on Geriatrics Gerontology & Palliative Nursing
Fernanda Barbisan, Moises H Mastella, Neida K Pellenz, Veronica F Azzolin, Cibele F Teixeira, Daise Raquel Maldaner, Antonio Flores Castro, Cibele Bessa Pacheco, Raquel de Souza Praia, Euler Esteves Ribeiro, Ednea Aguiar Maia Ribeiro and Ivana Beatrice Manica da Cruz
Federal University of Santa Maria, Brazil Lutheran University of Brazil, Brazil State University of Amazonas, Brazil
Posters & Accepted Abstracts: J Palliat Care Med
Abstract
Modification of body tissues, such as skin, over time leads to reduced tissue integrity due to decreased cell functions, among which the fibroblast is highlighted. Despite the many changes caused by cellular senescence, the most notable is the decrease in tissue healing capacity. In the search for therapies that improve biological functions, the barbatim�£o (Stryphnodendron adstringens (Mar.) Coville) is a plant native to Brazil with a well-known cicatrisation capacity, but little explored. Using the aged human fibroblast cell line (HFF-1), this study sought to demonstrate the potentialities of barbatim�£o extract in the modulation of cellular senescence genes, in anti-inflammatory action, proliferation, apoptosis and morphology. The results demonstrated the ability of the extract to increase the expression of senescence marker genes without, however, significantly altering cell proliferation, in addition to reducing mortality rates. Our results suggest that barbatim�£o is capable of restoring the metabolism of senescent skin cells.Biography
Fernanda Barbisan holds Bachelor’s degree in Biological Sciences, Master and PhD degree in Pharmacology. Currently, she holds a Postdoctoral degree in Gerontology. She is a Professor at the Federal University of Santa Maria-Brazil. She acts as a Researcher on projects that studies genetic-environmental interactions on the human aging and diseases associated with aging. She has experience in the areas of cellular aging and immunosenescence, toxicogenetics, nutrigenetic and pharmacogenetics, involving tests of modulation of oxidative stress, apoptotic and inflammatory cascade by toxic agents, functional foods and pharmacies. She has worked with molecular biology techniques for the evaluation of genetic variability, genetic polymorphisms, real time PCR, DNA damage, epigenetics, cell culture and biochemical, spectrophotometric and fluorimetric analyzes. She has participated in a Phase I clinical trial, using the drug Rosuvastatin and she has already designed and executed studies with humans, mainly with the elderly.
E-mail: fernandabarbisan@gmail.com
