Journal of Alzheimers Disease & Parkinsonism
Open Access

Abstract

Neurodegeneration induced by pathogenic proteins depends on contributions from surrounding glial. The main inflammatory players in AD are the glial cells which initiate the inflammatory response. One of the earliest neuropathological changes in AD is the accumulation of astrocytes at sites of Aβ deposition. Here it is demonstrated that the presence of astrocytes in a mixer culture (astrocytes and neurons) increase neuron survival, producing changes in oxidative stress and in the signalling between these cells. It is noted here, that stimulation of astrocytes with Aβ increased p-65 expression inside the NF-κB pathway, mitochondrial transcription factor A (TFAM) and peroxisome proliferator-activated receptor γ coactivador 1 (PGC-1) with markedly reduction of Sirtuins and peroxisome proliferator activated receptor γ (PPAR-γ). Protein over-expressions of TFAM and PGC-1 protect mitochondria against Aβ-induced damage by mitochondriogenesis. Obtained results support an astrocytes-neurons survival relationship with increase in mitochondriogenesis when astrocytes and neurons growth together, protecting neurons to the cell death.

Biography

Soraya L Valles has completed her PhD in 1996 from Valencia University and postdoctoral studies from Sheffield University School of Medicine. She is the director of Neuroscience group, at department of Physiology, Faculty of Medicine, and University of Valencia. She has published more than 25 papers in reputed journals and serving as an editorial board member of journals from Elsevier Editorial, Omics Editorial, etc. She has different grants from private and public companies. She is professor of different Masters Officials and not officials from CE, University of Valencia, etc.