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Association between catechol-O-methyltransferase (COMT) Val/Met genotype and smoking cessation treatment with nicotine: A meta-analysis
3rd International Conference on Clinical Pharmacy
Choi Hye Duck1 and Shin Wan Gyoon2
1Yeungnam University, Republic of Korea 2Seoul National University, Republic of Korea
Posters-Accepted Abstracts: Clin Pharmacol Biopharm
Abstract
COMT is one of the major degradative pathways of dopamine and COMT Val/Met polymorphisms are associated with the enzyme activity, which is related to dopamine involvement in the nicotine addiction process. However, the reported results of several genetic studies are not consistent. We reviewed the smoking cessation outcomes among previously reported studies by comparing COMT polymorphism. A total of five studies were assessed in the present meta-analysis and the Met/Met, Val/Met or Val/Val genotype were compared with respect to smoking cessation outcomes. As the results, any significant association between COMT polymorphism and smoking cessation were not observed. In the subgroup analysis, three studies were assessed for the association between the COMT polymorphism and smoking-cessation treatment with nicotine by comparing two groups (Met/Met vs. Val/ Met plus Val/Val). A significant association between COMT polymorphism and smoking cessation was observed (odd ratio=1.871 and 95% confidence interval 1.382��?2.534). In conclusion, the COMT polymorphisms are associated with the outcomes following smoking cessation treatment with nicotine.Biography
Email: chd80@hotmail.com
