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Antischistosomal Activity Of An Aromatic Diamidine Against Schistosomamansoni Adult Worms | 23499
ISSN: 2167-065X
Clinical Pharmacology & Biopharmaceutics
Open Access
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Antischistosomal activity of an aromatic diamidine against Schistosomamansoni adult worms
2nd International Summit on Clinical Pharmacy
Rivelilson Mendes de Freitas, George Laylson da Silva Oliveira, Glaucio Barros Saldanha, Andr� Augusto Gomes Faraco, Pedro Luiz Silva Pinto,
Josu� de Moraes4 and Anderson Jos� Ferreira
The present study reports the antischistosomal activity of a molecular entity of synthetic origin and derived from diminazene
in an experimental in vitromodel against Schistosomamansoni.This derivative of diminazene is an aromatic diamide
that at concentrations of 125, 250 and 500 μg/ml induced a significant reduction in the motor activity and high mortality
rates of S.mansoni adult worms of both sexes. At concentrations of 125, 250 and 500 μg/ml, the derivative of diminazene
caused the death of 100% of adult parasites of S. mansoni of both sexes at the time of 48 hours.Confocal laser scanning
microscopyanalysis following flaking and disintegration of tubers studies revealed morphological changes in the tegumental
surface of maleS. mansoni worms treated with the aromatic diamide resulting in the disappearance of swollen buttons.Also, it
was observed that the derivative of diminazene at concentrations of 62.5, 125 and 250 μg/ml has the capability of reducing by
100% theoviposition when compared with the number of eggs produced by S. mansoni worms ofthe control group.Thus, the
present studydescribed thein vitroantischistosomal activity of a compound derived from the diminazene through observations
in the mortality rate, reduction in motor activity, alterations in the tegument and oviposition of adultS. mansoni worms.In vivo
studies are needed usingthis derivative of diminazene to elucidate its mechanisms of action and to determine its full potential
to develop a newantiesquistossomose drug.
Biography
Rivelilson Mendes de Freitas has Master and PhD degree in Pharmacology atthe Federal University of Cear�. Postdoctoral fellow at the Faculty of Pharmacy of
University of Coimbra and at the Redox Biology in Health and Disease Research Group of the Centre of Neurosciences and Cell Biology. Currently, he is Adjunct
professor III of Undergraduate Course in Pharmacy and Vice Coordinator of the Graduate Program in Pharmaceutical Sciences of the Federal University of Piau�
(UFPI).
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