Journal of Biotechnology & Biomaterials
Open Access

Abstract

This research was aimed to study and evaluate the antimicrobial activity of a novel 2-methylsulfanyl-[1,2,4]triazolo[1,5-a] quinazoline and its derivatives. Antibacterial activity of the target compounds was tested against a variety of species of gram positive bacteria as Staphylococcus aureus ATCC 29213, B. subtilis ATCC6633 and gram negative bacteria as Pseudomonas aeroginosa ATCC27953 and E. coli ATCC 25922. In addition to some yeast and fungi as Candida albicans NRRL Y-477 and Aspergillus niger were screened. Antimicrobial tests were carried out by the agar well diffusion method, 28 using 100 μL of suspension containing 1 x108 CFU/mL of pathological tested bacteria ,1 x106 CFU/ml of yeast and 1x104 spore/ml of fungi spread on nutrient agar (NA), Sabourand dextrose agar (SDA), and potato dextrose agar (PDA) respectively.

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