Journal of Traditional Medicine & Clinical Naturopathy
Open Access

Abstract

Asthma is a chronic inflammatory lung disease characterized by airway hyper responsiveness (AHR), airway obstruction and airway wall remodeling responsible for significant morbidity and mortality worldwide. There are no the exact causes of asthma, lots of researchers think that genetic and environment factors may result in asthma. Chungpye-tang (CPT) has been used as traditional prescription of asthma in Korea. CPT composed 4 species of herbal medicines was prformed extraction with distilled water for 3h at 100�°C. In this study, we investigated the precise mechanism of the anti-inflammatory effect of CPT by western blotting analysis and whether the decoction extracts could reduce pro-inflammatory cytokines such as TNF-�±, eotaxin, IL-4, IL-9 and IL-13 in IL-1�²-induced inflamed asthmatic human airway epithelial tissue by multiplex cytokines array. As results of this study, there was a trend toward decreased NF-�ºB expression in asthmatic human airway epithelial tissue. IL-9 and IL-13 secretion was significantly reduced in the lung tissue treated with CPT. Overall, our results indicate that CPT has an anti-inflammatory effect through blocking the signaling pathway of NF-�ºB, thereby CPT may be a potential remedial agent for allergic ashtma.

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