Clinical Pharmacology & Biopharmaceutics
Open Access

Abstract

Despite the introduction of potent antiemetic drug in the hospital formularies in Turkey, the CINV is still an ongoing problem that required research and investigation. The study aimed to highlight one of the factors which may cause impaired antiemetic therapy response. An observational prospective study was conducted in Marmara Pendik education and Research Hospital in Istanbul Turkey, to determine the impact of antiemetic guidelines consistency on the incidence of CINV. 100 naive patients who received chemotherapy for the first cycle were participating in the study. The antiemetic prescribing patterns and the consistency of the guidelines were assessed according to MASCC/ESMO and NCCN, 2014. Patients were given a daily diary to record the incidence of nausea and vomiting where Likert scale was used to record the severity of nausea, the incidence of CINV was recorded from day 1 to day 5 to determine both the acute and delayed phase of nausea and vomiting. Three outcomes were used to describe the CINV: (a) complete response (no emetic episodes and no rescue therapy); (b) complete protection (no emetic episodes, no rescue therapy, and no significant nausea [Likert score 2 or less]); and (c) complete control (no emetic episodes, no rescue therapy, and no nausea). Data analysed using SPSS chi-square test, Mann-Whitney and Kruskal Wallis test. Results show that guidelines, consistency was 80% for acute CINV and only 28% of delayed CINV guidelines, and there is a significant difference (p<0.01) and categorical dependence between the incidence of acute and delayed nausea in the patients who received antiemetic with consistency to guidelines and those not in the first cycle and second cycle (p<0.05) where consistent with guidelines associated with a high percentage of complete control. Conclusion: Increased consistency with the guidelines could significantly reduce incidence of CINV.

Biography

Email: nibal.abunuhlah@kemerburgaz.edu.tr