Journal of Clinical & Experimental Pathology
Open Access

Abstract

The objective of this study is to correlate the morphometric microvascular characteristics of the breast cancer in the peripheral and internal areas of the tumor with the prognostic factors. Histologic sections from 80 cases of infiltrative breast cancer were immunostained with CD34 and evaluated with the image analysis IMAGE J program following the method of Giatromanolaki A., et al. The microvascular count is significatively higher in the tumor margin with gradual decrease toward the internal areas. The microvascular count in both tumoral areas peripheral and internal associated with the tumor size, histological grade and vascular invasion. The microvascular count in the peripheral area show association with the expression of cerbB-2, ki67, while in the internal area associated with the expression of cerbB-2, ki67 and p53. In the peripheral area the decrease of vascular perimeter and compactness and the increase of the factor of shape associated with higher histologic grade. Whereas the decrease of compactness and increase in the factor of shape associated with the positive expression of cerbB-2 and negative expression of estrogen receptor. Regarding the microvasculature in the internal tumoral area the increase of the area, perimeter and ferret (all represent increase vascular size) associated with the expression of ki67, whereas the area associated with the vascular invasion, indicating that in the peripheral tumoral area microvasculature with smaller perimeter and more regular and circular shape associated with poor prognostic factors while in the internal tumoral area microvasculature with larger caliber associated with tumors more proliferative and invasive.

Biography

Email: munawazeer@gmail.com