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An automated method to compute bone marrow density and M:E ratios from H&E slides
9th World Digital Pathology & Pathologists Congress
Cleopatra Kozlowski, Gary Cain, Paula Katavolos and Jacqueline Tarrant
Genentech Inc., USA
Posters & Accepted Abstracts: J Clin Exp Pathol
Abstract
Bone marrow toxicity is an important safety signal in a large variety of pre-clinical drug development programs. Currently, bone marrow cellularity is assessed semi-quantitatively by manual examination of H&E slides by a pathologist. Changes in M:E (Myeloid:Erythroid) cell ratios are challenging to estimate manually from H&E slides. For more accurate assessment, it is necessary to perform a manual differential cell count on bone marrow cytology smears. Both manual procedures are time and resource-intensive. A more efficient quantification process would provide a means to rapidly screen a larger number of slides from studies which exhibited and/or anticipated bone marrow toxicity. An entirely automated image analysis program was designed using Definiens Developer which quantifies changes in overall bone marrow cellularity and approximates M:E ratios and megakaryocyte density in H&E slides. Preliminary validation studies in rats indicate that the automated results correlate well with manual assessment.Biography
Email: kozlowski.cleopatra@gene.com
