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Vera P. Krymskaya
ScientificTracks Abstracts: J Clin Exp Pathol
Vera P. Krymskaya, Ph.D., Associate Professor of Medicine, has dedicated the last several years of her career to combating LAM. Krymskaya?s lab was responsible for the breakthrough step of discovering the function of the TSC2 gene. Dr. Krymskaya linked mutational inactivation of TSC2 in human LAM cells to the constitutive activation of mTORC1 and abnormal LAM cell growth. Dr. Krymskaya has also advanced translational LAM research by demonstrating that rapamycin inhibits LAM cell growth. This discovery identified rapamycin as a promising therapeutic strategy for LAM patients, and paved the way for rapamycin clinical trials worldwide.
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