Spanish 
Chinese 
Russian 
German 
French 
Japanese 
Portuguese 
Hindi Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers
Google Scholar citation report
Citations : 3330
Journal of Biotechnology & Biomaterials received 3330 citations as per Google Scholar report
Indexed In
- Index Copernicus
- Google Scholar
- Sherpa Romeo
- Open J Gate
- Genamics JournalSeek
- Academic Keys
- ResearchBible
- China National Knowledge Infrastructure (CNKI)
- Access to Global Online Research in Agriculture (AGORA)
- Electronic Journals Library
- RefSeek
- Hamdard University
- EBSCO A-Z
- OCLC- WorldCat
- SWB online catalog
- Virtual Library of Biology (vifabio)
- Publons
- Geneva Foundation for Medical Education and Research
- Euro Pub
- ICMJE
Useful Links
Recommended Journals
Related Subjects
Share This Page
In Association with
Altered adipogenesis under micronutrient deficiency: In vitro approach using mesenchymal stem cells
6th World Congress on Biotechnology
Vijayalakshmi Venkatesan, Sireesha G, Rajanna A, Venkata M, Sowmya K and Raghunath M
National Institute of Nutrition, India
ScientificTracks Abstracts: J Biotechnol Biomater
Abstract
Early intrauterine nutritional insult combined with lifestyle changes have been well documented to increase the risk of adiposity and associated chronic diseases (CDs) during adulthood. Indeed, inflammation in visceral adipose depot has been pinned down as the major confounding factor underlining the CDs which include insulin resistance (IR), obesity, T2 diabetes, CVD, hypertension etc., having significant impact at global scenario. In this context, development of model systems (in vitro and in vivo) have immensely helped to bridge the gap towards understanding the pathophysiology of CDs, yet the mechanisms are still obscure. The present study has been explored the feasibility of BM-MSCs as an in vitro model to delineate the mechanisms underlying folic acid deficiency in situ vis a vis to understand the developmental vs. nutritional programming with reference to adipogenesis. Our findings are in agreement with the reported in vivo data to support for an altered adipogenesis with up-regulated inflammation. We have demonstrated for an induction in visceral adipocity with increase in triglyceride levels and mRNA of visfatin and leptin. Further, inflammation, apoptosis and oxidative stress were all significantly increased as compared to controls (MNC). This study forms the basis to report for the first time, application of BM-MSCs as an in vitro model system to study nutritional programming (deficiency/over nutrition) to recreate physiological milieu akin to intrauterine conditions.Biography
Vijayalakshmi Venkatesan has completed her PhD in Biochemistry (National Institute of Nutrition) awarded from Osmania University, Hyderabad, India. She has pursued Postdoctorate from CCMB followed by induction as a Senior Faculty in Liver Research Centre at Hyderabad, India. In 2002, she was recruited as Assistant Director at National Institute of Nutrition (ICMR) and initiated the area of Stem Cell Research and she is currently Scientist F. She has more than 60 papers in peer reviewed journals and has been in the Advisory Board of several stem cell centers in India. She has also received the prestigious Biomedical Fellowship from Government of India to visit Karolinska Institute, Sweden.
Email: v.venkateshan@gmail.com
