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Alpha cyano-4-hydroxy-3-methoxycinnamic acid inhibits proliferation and induces apoptosis in human breast cancer cells
2nd World Congress on Bio Summit & Molecular Biology Expo
Lamia Hamdan Ramdani, Zoheir Arrarz, Yacoub Al Muataz, Lutfi Suleiman
Centre de Recherche Scientifiqueet Technique en Analyses Physico-Chimiques, Algeria University of Auvergne, France
Posters & Accepted Abstracts: J Biotechnol Biomater
Abstract
Breast cancer is the leading cause of cancer death in women worldwide and a critical public health concern. In this context, the present work has examined the in vitro and in vivo antiproliferative and pro-apoptotic effects of �±-cyano-4-hydroxy- 3-methoxycinnamic acid ACCA on human breast cancer cell lines, MDA-MB-231, MCF-7 and T47D. Treatment with ACCA resulted in dose and time-dependent decrease of cell proliferation, viability in colony formation assay and in induction of programmed cell death (apoptosis) with minimal effects on non-tumoral cells. The ability of ACCA to suppress growth in cancer cells not expressing or containing defects in p53 gene indicates a lack of involvement of this critical tumor suppressor element in mediating ACCA-induced growth inhibition. The stimulation of breast cancer cells with ACCA would increase the expression of the ratio of Bax to Bcl-2, a process widely involved in the stimulation of apoptosis. Besides, we have demonstrated the ability of ACCA to inhibit the migration and invasion of MDA-MB231 cells. Additionally, tumor growth of MDA-MB-231 breast cancer cells was dramatically affected in vivo by ACCA. Therefore, these results show that ACCA might be very promising therapeutic targets in the treatment of breast cancer.Biography
Email: lamia_pharm@yahoo.fr
