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In Association with
AFM mapping the receptors on breast cancer cells
Annual Conference and Expo on Biomaterials
Biran Wang
City College of New York, USA
Posters & Accepted Abstracts: J Biotechnol Biomater
Abstract
Targeted cancer therapy is a powerful tool to localize drugs to the tumor site. In this project, we identified some of very important receptors as therapeutic targets, such as, CXCR4 (C-X-C chemokine receptor type 4), ICAM1 (Intercellular Adhesion Molecule 1) integrins, etc., they are all overexpressed on breast cancer cells and either trigger cell migration or/and promote metastasis. To date, the dynamic assembly of those receptors on the cell surface as the mediators of receptor binding is not well characterized. The objective of this work is to quantify the density, spatial organization and magnitude of binding of those receptors on live metastatic breast cancer (MBC) cells. We measured the Young's modulus, the receptors surface density and their unbinding forces on MBC cells by atomic force microscopy. We conclude that the receptor density, spatial organization and matrix stiffness are paramount to achieve strong binding.Biography
Email: wangbiran@gmail.com
