Clinical Pharmacology & Biopharmaceutics
Open Access

Abstract

Background: Pulmonary tuberculosis is a major cause of morbidity and mortality worldwide, resulting in the greatest number of deaths due to any one single infectious agent. Drug resistance threatens global tuberculosis control efforts. Objective: The aim of this study was to assess adverse reactions of second-line TB drugs in patients treated for MDR-TB at Abbassia Chest Hospital from 1st of January 2009 to 1st of January 2012. Subjects & Methods: This study included 107 patients admitted at Abbassia Chest Hospital; during the period from January 2009 to January 2012. The patients were resistant to at least rifampicin and INH. All patients� files were analyzed and the following data were discussed: meticulous history taking, complete clinical examination, drug susceptibility testing, and initial laboratory investigations, adverse reactions were determined by clinical criteria and/or laboratory data, severity code, management of side effects and fate of treatment. Results: 72.9% of the patients were males and 27.1% were females. The mean of age was 37.1 years. The special habits detected among the studied cases were tobacco smoking, drug addiction and alcohol intake. According to type of resistance, acquired resistance was 95.3% and primary resistance was 4.7%. The most common co-morbidities associated with MDR-TB in the studied cases were diabetes (29.9%) and chronic obstructive lung disease (11.2%). Side effects of drugs were; 57% GIT manifestations, 53.3% peripheral neuritis, hypokalemia 26.2%, irritable bowel syndrome 22.4%, ototoxicity 17.8%, skin reaction 10.3%, hypothyroidism 10.3%, hepatotoxicity 9.3%, hypoalbuminemia 5.6%, depression 3.7%, arthritis 0.9%, gynecomastia 2.8%.

Biography

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