Journal of Gastrointestinal & Digestive System
Open Access

Abstract

Background and Aim: The potential role of Adiponectin, Leptin, IGF1 and TNF�± as biomarkers in colorectal adenoma is not clear. Therefore, we aimed to investigate the blood serum levels of these biomarkers in colorectal adenoma. Method: The case-control study consisted of serum from 180 African American patients with colon adenoma (cases) and 198 healthy individuals (controls) at Howard University Hospital. We used ELISA for Adiponectin, Leptin, IGF1 and TNF�± detection and quantification. Statistical analysis was performed by t-test and multivariate logistic regression. Results: The respective differences in median Leptin, Adiponectin, IGF1 and TNF�± levels between control and case groups (13.9 vs. 16.4), (11.3 vs. 46.0), (4.5 vs. 12.9) and (71.4 vs. 130.8) were statistically significant (p<0.05). In a multivariate model, the odds ratio (ORs) for Adiponectin, TNF�± and IGF1 were 2.0 (95% CI=1.6â��2.5; P<0.001), 1.5 (95% CI=1.5â�� 2.0; P 0.004) and 1.6 (95% CI=1.3â��2.0; P< 0.001), respectively. There was a positive correlation between serum Adiponectin and IGF1 concentrations with age (r=0.17, P< 0.001 and r=0.13, P=0.009), TNF�±, IGF1 and Leptin concentration with Body Mass Index (BMI) (r=0.44, P< 0.001; r=0.11, P=0.03 and r = 0.48, P<0.001), respectively. Also, there was a negative correlation between Adiponectin and Leptin concentration with BMI (r=-0.40, P<0.001 and), respectively. Conclusion: These data support the hypothesis that Adiponectin, IGF1 and TNF�± high level are increasing the risk of colon adenoma and can be applied for colorectal adenomas risk assessment.

Biography

Email: hashktorab@Howard.edu