Clinical Pharmacology & Biopharmaceutics
Open Access

Abstract

Air and moisture stable coordination compounds of first transition metals such as Co (II), Ni (II) and Cu (II) with newly designed Schiff base (bsiph) incorporating 5-bromosalicyaldehyde (bs) with isatin and 4-nitro-o-phenylene diamine (nph) have been synthesized. The molecular structure of ligand and its complexes were characterized by elemental analyses, IR, 1H and 13C NMR, TGA and electronic spectroscopy. Conductivity and magnetic susceptibility measurements were used to elucidate the structure of the newly prepared metal complexes. The analytical and spectroscopic tools suggested that the prepared Schiff base ligand behave as mono basic tetra-dentate ONNO ligand and bind to metal (II) ion in octahedral geometry according to the general formula [M(bsiph)x(H2O)].n(H2O) where M=Cu(II), Co(II) and Ni(II), x=OAC-, NO3- and n=number of hydrated water molecules. The binding properties of the investigated complexes with Calf thymus (CT-DNA) were investigated by using electronic spectra and viscosity measurements. Moreover, DNA cleavage activity of the prepared Schiff base complexes was monitored by gel electrophoresis. Furthermore, the Schiff base and its complexes were screened for antimicrobial activity against gram positive bacteria (Staphylococcus aureus), gram negative bacteria (Escherichia coli, Pseudomonas aeroginosa) and fungi (Aspergillus flavus, Candida albicans and Trichophyton rubrum). The results showed that the metal complexes were more reactive with respect to its ligand.

Biography

Email: ahmed_benzoic@yahoo.com