Journal of Gastrointestinal & Digestive System
Open Access

Abstract

To test the hypothesis that Roux-en-Y gastric bypass (RYGB) alters meal size (MS) and intermeal interval (IMI) length by exogenous cholecystokinin (CCK)-8 and CCK-33 and changes thegastrointestinal sites of actions regulatingthem,we measured these feeding responses following infusion of the peptides (0.05 and 0.1nmol/kg) in the celiac artery (CA, supplies stomach and upper duodenum) and the cranial mesenteric artery (CMA, supplies small and part of the large intestine) in modified RYGB (in which part of the stomach is removed) rats. We found that CCK-8 (0.05 and 0.1nmol/kg) given in the CMA reduced MS and prolonged the IMI CCK-33 (0.05 and 0.1nmol/kg) reduced MS and prolonged the IMI in the CMA group greater than CCK-8.In conclusion, modified RYGB alters MS and IMI length by exogenous CCKand the gastrointestinal sites of actions regulating them. Changes in the architecture of the gut which leads to possible redistribution of the CCK receptors following the RYGB surgery, may explain some of these findings.

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