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conferenceseries
.com
July 17-19, 2017 Chicago, USA
World Congress and Expo on
Optometry & Vision Science
Volume 2, Issue 1 (Suppl)
Optom Open Access, an open access journal
ISSN:2476-2075
World Optometry 2017
July 17-19, 2017
Correlation between tear film lipid layer and symptoms in diabetic patients with meibomian gland
dysfunction
Johanna Garzón P
1
,
2
and
Antonio López-Alemany
2
1
La Salle´s University, Colombia
2
University of Valencia, Spain
Purpose:
To assess the tear film lipid layer pattern in type 2 diabetes patients and healthy subjects, the correlation of the
symptoms between the Ocular Surface Disease Index (OSDI) symptom questionnaire and the National Eye Institute Vision
Functioning Questionnaire (NEI-VFQ).
Methods:
This is a case-control study and all patients were investigated for the presence of meibomian gland dysfunction/
MGD using the International Work Shop in MGD’s criteria according to the meibomian glands/MG secretion’s quality and
viscosity, MG’s morphology, and lipid layer thickness/LLT. The LLT was measured using interferometry Polaris system prior
and subsequent to a 10-minute period. The Ocular Surface Disease Index (OSDI) symptom questionnaire and the National
Eye Institute Vision Functioning Questionnaire (NEI-VFQ) were correlated. The results between groups were analyzed using
the statistical Kruskal-Wallis and Mann-Whitney tests association between variables was explored by Spearman’s correlation.
Results:
73 subjects were studied (37 diabetics and 36 controls). The mean age was 59±8.7% of participants presented MGD
(76% diabetics and 67% controls).The symptoms through OSDI questionnaire was significantly higher (p=0.016) in the diabetic
group with a lower NEI VFQ (67.86; p=0.002). The lipid layer pattern was lower in diabetic patients group with DGM; NIBUT
was lower in the diabetic group (sg 2.47±1.2), with a significant inverse correlation (52.22%) with MG inflammation and a
moderate correlation (32.4%) with corneal staining. The LLT presented a positive correlation between the meibomian gland
alteration as hyperkeratinisation and inflammation (p=0.0005) and symptoms. Positive correlations were found in diabetic
group between corneal staining and symptoms with OSDI questionnaire.
Conclusions:
A correlation was found between NIBUT, inflammation and obstruction of the MG in symptomatic type 2
diabetes patients. The LLT is lower in diabetic group than in normal subjects, which implies decreased tear film stability and
increased subjective symptoms associated with a decreased quality of life.
Biography
Johanna Garzón P is a candidate of Doctor with PhD in Advanced Optometry and Vision Sciences in Advanced at Valencia University, Spain. She is an Optometrist
of The Salle University, Specialist in Ocular Primary Careat Andina University FUAA-Colombia, Master’s in Pharmacology Sciences at National University of
Colombia, UNAL. She has her expertise and research job in ocular surface, dry eye and ocular pharmacology. She is titular Professor at the Salle University in
Bogotá Colombia, and is the President of Fedopto, the Professional College of Optometry in Colombia.
johannagarzonparra@icloud.comJohanna Garzón P et al., Optom Open Access 2017, 2:1 (Suppl)
DOI: 10.4172/2476-2075-C1-002