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conferenceseries
.com
July 17-19, 2017 Chicago, USA
World Congress and Expo on
Optometry & Vision Science
Volume 2, Issue 1 (Suppl)
Optom Open Access, an open access journal
ISSN:2476-2075
World Optometry 2017
July 17-19, 2017
Optom Open Access 2017, 2:1 (Suppl)
DOI: 10.4172/2476-2075-C1-003
Efficacy of chloroquine-doxycycline combination therapy on co-infection of malaria and onchocerciasis
in ahani-achi
Akujobi, A.U
Bausch & Lomb school of optometry, Algeria
T
he clearance rates of separate and combination therapies of chloroquine and doxycycline on malaria, onchocerciasis
and mixed onchocerciasis-malaria parasitemia in 603 volunteers aged 10-60+ years were investigated for baseline and
post-intervention mean parasite densities (MPD) using skin snip biopsy and smear microscopy techniques between March
2012 and April 2014. Subjects were classified into onchocerciasis (n=100), onchocerciasis+ chloroquine-doxycycline therapy
(n=90), malaria (n=104) and concomitant onchocerciasis-malaria (n=309) groups. Standard treatment with doxycycline
was 200mg daily dose for 6 weeks while that of chloroquine was 1000mg loading dose, followed by 500mg after 6-8 hours,
then 500mg each day for 2 days. Result showed that the clearance rates of chloroquine-doxycycline, chloroquine-only and
doxycycline-only on concomitant onchocerciasis-malaria parasitemia were 100%, 94.12% O. volvulus; 52.97% MP and 100%
O. volvulus; 97.70% MP respectively. Chloroquine was shown to potentiate the microfilaricidal action of doxycycline. Chi-
square (X2) analysis showed that the difference between the clearance rates of combination therapy and chloroquine-only
therapy on concomitant onchocerciasis-malaria parasitemia was statistically significant (P<0.05) while the difference between
the clearance rates of combination therapy and doxycycline-only therapy on mixed parasitemia was not statistically significant
(p>0.05). In conclusion, Chloroquine-doxycycline combination therapy proved effective as a novel therapeutic strategy in the
management of separate and co-infection of malaria and onchocerciasis.
drakujobi@yahoo.com