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Volume 6, Issue 2 (Suppl) Virol-mycol
ISSN: 2161-0517 VMID, an open access journal Virology Asia 2017
May 11-12, 2017
Page 40
Notes:
conferenceseries.com
May 11-12, 2017 Singapore
10th World Congress on
Virology and Mycology
Neurologic complications of dengue virus infection
Statement of the Problem: Dengue virus infection is an extremely common mosquito borne infection in the world. Neurologic
complications are increasingly being reported in dengue cases affecting both the central and peripheral nervous system. This
session is aimed to discuss the incidence and clinical spectrum of neurologic complications of dengue, methods of their
diagnosis, management and outcome in patients with dengue virus infection.
Methodology & Theoretical Orientation: An extensive review of the published literature was carried out using PubMed,
Scopus and Google Scholar databases. The keywords used were: “Dengue AND Neurological”, “Dengue AND Neuropathy”,
”Dengue AND Plexopathy”, “Dengue AND Acute Encephalitis Syndrome”, “Dengue AND Encephalopathy”.
Findings: The neurologic manifestations may be seen in 0.5-7.4% of dengue cases. These include encephalopathy,
encephalitis, aseptic meningitis, stroke (intracranial hemorrhages or thrombosis), myelitis, Guillain Barre syndrome, plexus
involvement (brachial plexopathy, neuralgic amyotrophy, lumbosacral plexoopathy), nerve involvement (mononeuropathies,
polyneuropathies) and muscle involvement (myalgias, myositis, rhabdomyolysis, hypokalemic paralysis). Diagnosis of dengue
virus infection may be made by a combination of dengue NS1Ag/Real Time PCR and anti-IgM antibody in CSF. In serum
samples, dengue infection may be confirmed by PCR/culture positivity, IgM detection or by four fold rise in titers of specific
IgG antibodies in paired serum samples.
Conclusion & Significance: In endemic regions, dengue should be considered as a differential diagnosis of neurological
disorders. Early recognition of these complications is required for proper management of cases and for preventing further
disabilities.
Biography
Amita Jain is a multifaceted Medical Teacher who has contributed immensely in the Field of Microbiology. She has worked in many areas of Medical Microbiology includ-
ing Tuberculosis, Bacteriology and Virology. She is a keen Researcher and has successfully completed many research and public health projects and published several
papers, some of which are highly cited. She has guided 24 PhD students and provided guidance to many Under-graduate and Post-graduate students. She has estab-
lished new diagnostic and research facilities, which are of immense help to medical students, researchers and patients. She has investigated several epidemics of swine
flu, dengue, acute encephalitis, hepatitis, drug resistant TB, etc. She has provided diagnostic services to Uttar Pradesh State Health Services in the field of Virology and
Tuberculosis. She has organized trainings for laboratorians and community awareness health programs.
Amita Jain
King George’s Medical University, India
Amita Jain, Virol-mycol 2017, 6:2 (Suppl)