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Volume 09
February 15-16, 2019 Amsterdam| Netherlands
Vascular Dementia
11
th
International Conference on
Vascular Dementia 2019
Journal of Alzheimers Disease & Parkinsonism | ISSN : 2161-0460
Very low density and low density lipoprotein contribution to vascular
dementia (VD)
T
raditional lipid profiles do not identify the risk of VD that are caused by the presence of
small dense LDL and IDL particles. Dangerous LDL particles may hide behind normal
cholesterol levels and, conversely, elevated cholesterol levels do not inevitably have to be
associated with a VD risk. Studies (eg Reitz
et.al.2004) have shown that the classical lipid
profiles of patients with coronary artery diseases do not significantly differ from those of
healthy persons. LDL cholesterol, the lipid that is mostfrequently associated with vascular
dementia, is heterogeneous and consists of up to seven sub-fractions. Large circulating
LDL particles are less atherogenic. This paper analyses subjects’ lipoprotein into five
major classes: chylomicrons, very low density lipoprotein (VLDL), intermediate density
lipoprotein (IDL), low density lipoprotein (LDL) and high density lipoprotein (HDL).
Half of subjects without vascular dementia have higher cholesterol levels. A considerable
portion of vascular dementia patients have low cholesterol levels. Individual differences
exist in particular with respect to the LDL levels and here, even more importantly, in the
size distribution of the LDL particles. The small LDL particles in particular have a very
high atherogenic potential. It is less important how much cholesterol a patient has, but
which type of cholesterol is elevated and which size distribution the cholesterol particles
have. These are the parameters the risk assessment and thetreatment should focus on.
Biography
Edward Chan has completed his Masters in Nutritional Medicinewith theSociety for Advancement of Hormones
& Healthy Aging Medicine Malaysia, Masters in Learning from Lancaster University, UK and Doctorate in
Psychology from the Intercultural Open University School of Medicine. He is the principal consultant of
WellLab, a premier laboratory diagnostic testing organisation. He has published numerous papers in reputed
journals and has been serving as an editorial board member of repute.
edward@psychology.com.myEdward Chan
WellLab, Malaysia
Edward Chan, J Alzheimers Dis Parkinsonism 2019, Volume 09
DOI: 10.4172/2161-0460-C1-060