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February 15-16, 2019 Amsterdam| Netherlands
Vascular Dementia
Vascular Dementia 2019
Journal of Alzheimers Disease & Parkinsonism | ISSN : 2161-0460
11
th
International Conference on
Volume 09
Hans von Holst, J Alzheimers Dis Parkinsonism 2019, Volume 09
DOI: 10.4172/2161-0460-C1-059
A new hypothesis on the etiology to dementia in traumatic brain
injury and stroke
I
ncreased intracellular water content defined as cytotoxic brain tissue edema is a
serious secondary clinical complication to traumatic brain injury (TBI) and stroke
and without knowledge to the etiology. Recently, a hypothesis to the nervous tissue
edema was presented suggesting that external dynamic and internal mechanical static
impact forces caused protein unfolding resulting in an increased brain tissue water
content and what happens with the metabolism in the long run. The hypothesis was
confirmed by computer simulation tests. In this laboratory study, we further evaluated
the hypothesis by using the mature protein laminin LN521 upon the effects of both
dynamic as well as static impact forces, respectively. The treated laminin solutions
were then analyzed with denatured electrophoresis and electron microscopy showing
aggregation and fragmentation of the laminin structures. The present laboratory
results confirm earlier hypothesis and computer simulation suggest for the first time
that dynamic impact force in an accident and increased mechanical static force in
stroke unfold mature proteins having the potential to increase the intracellular water
content defined as cytotoxic brain tissue edema. The clinical condition resembles the
phenomenon when elasmobranchs including white sharks prevent their cells from too
high hydrostatic pressure in the deep sea. Thus, the present laboratory study results and
knowledge from marine physics may be considered to improve the clinical treatment
and outcome of TBI and stroke patients. This opens up new perspectives how vascular
dementia in TBI and stroke should be looked upon when it comes to clinical treatment.
Biography
Hans von Holst has received his MD degree in 1976 and Specialist in Neurosurgery in 1982, at Karolinska University
Hospital. In 1985, he earned his PhD and Associate Professorship in Neurosurgery, Clinical Neuroscience from
Karolinska Institutet and has been appointed as Senior Neurosurgeon from 1988-2015. During 1991-1996, he was
Chairman of the Department of Neurosurgery and Division Manager of the Neuro Clinics at Karolinska University
Hospital, respectively. In between 1994-2014, he was appointed as Professor in Neuro Engineering at KTH Royal
Institute of Technology and visiting Professor at Karolinska Institutet from 2006-2012. He has published over 150
original papers in reputed journals, published reviews and books and served as Editorial Board Member for several
journals.
hvh@cenesy.comHans von Holst
Karolinska University Hospital , Sweden