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February 15-16, 2019 Amsterdam| Netherlands
Vascular Dementia
11
th
International Conference on
Volume 09
Vascular Dementia 2019
Journal of Alzheimers Disease & Parkinsonism | ISSN : 2161-0460
Cerebral morphological and cognitive status in long-term period after CABG
Stanislav Semenov
1
, Syrova I D
1
, Portnov Yu M
1
, Maleva O V
1
, Trubnikova O A
1
, Semenov A S
2
, Kovalenko A V
1
and Barbarash O L
1
1
Research Institute for Complex Issues of Cardiovascular Diseases, Russia
2
Praxis Wolfgang Theobald Facharzt für Radiologie, Germany
Purpose:
The main purpose of this study was to estimate of brain morphological pattern and cognitive status changes and after
CABG in long-term postoperative period.
Material & Methods:
The study included 75 male patients (62.5±5.5y) with initial Beck scale is not more than 16, MMSE is not
less than 24, FAB scale 11 points. Before and five years after, CABG patients were examined in STAI, MMSE, FAB scales and brain
MDCT.
Results:
Five years after CABG there was significant reduction in STAI (initial - 20.0 [17.0, 23.0], after - 22.0 [19.0, 27.0], p<0.05),
the preservation of cognitive status on the MMSE (initial - 28 [27, 29], after - 27 [26; 28], p<0.05) and FAB (initial - 16 [14, 17],
after - 17 [16, 17], p<0.05). Only two patients developed dementia. Third (III) ventricle width pre/after - 6.86±1.91 mm/8.45±2.18
mm, p=0.001, ventricular cranial index Evans – 29%/31%; the presence of leukoaraiosis was detected in 18 (31.03%) patients/44
(66.67%), p=0.001, cysts and gliosis were found in 2 (3.45%) patients/24 (36.36%), p=0.0001.
Conclusion:
During five years after CABG, the majority of patients revealed the worsening in the cerebral morphological structure
in the form of enlargement of its ventricular system, increase in the number of patients with leukoaraiosis, cysts and gliosis areas.
These structural changes in the brain on MDCT indicate a progression of chronic cerebral ischemia in the long-term postoperative
period, despite the preservation of cognitive status in screening neuropsychological testing.
J Alzheimers Dis Parkinsonism 2019, Volume 09
DOI: 10.4172/2161-0460-C1-061