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Volume 6 Journal of Infectious Diseases & Therapy Tropical & Bacterial Diseases 2018
December 05-06, 2018
Page 28
Notes:
conferenceseries.com
Annual Conference on
Bacterial, Viral and Infectious Diseases
&
Neglected Tropical Diseases Congress: The Future Challenges
December 05-06, 2018 Dubai, UAE
Role of HPV 6/11 in giant condyloma in Indian patients
Uma Nahar Saikia, Suvradeep Mitra, Tirupti Rangta, Mini P Singh and Dipankar De
PGIMER, India
Introduction: Genital warts are quite common in sexually active population with Human Papilloma Virus (HPV) as the
causative agent. In western literature HPV6/11 as an etiological factor varies from 80 to 90%, however there is a paucity of
literature in India about the type of virus causing condylomata.
Material & Methods: A total of 22 histologically confirmed cases of condylomata acuminata were included in the study over
a period of 2 years (2014-2016). The majority (19/22; 86.3%) of the biopsy samples were from genital and perianal areas.
Formalin Fixed Para-film (FFPE) embedded sections were used for HPV 6 and 11 using 2-3, 20-30 micron sections. The targets
used were L1 and E6 region of HPV 6 and 11, respectively.
Result: Clinically, 18 patients had giant condyloma and 4 had multiple lesions. There was male preponderance (95.4%) with
mean age of 46.3 (18-84 years). Histologically marked acanthosis with papillomatosis was noted. There was moderately dense
lymphoplasmacytic infiltrate in the upper dermis with vascular proliferation. Koilocytic change was seen in 10 (71.4%) cases
which correlated with PCR positivity in 10 cases. On PCR 14 cases (63.6%) were positive for HPV 6 or 11; HPV 6 alone
was present in eight cases (36.3%) and HPV 11 in six cases (27.2%). No dual infection was present. The HPV 6/11 positivity
correlated with higher degree of inflammation. Three cases with clinical diagnosis of syphilis, Ewing’s sarcoma and carcinoma
breast, respectively were negative for HPV 6 and HPV 11.
Conclusion: The PCR results confirmed the presence of HPV6/11 in 63.6% of condylomata acuminata cases. Five
morphologically confirmed cases were negative for HPV 6 and 11, possibly due to late stage of infection with no significant
inflammation or koilocytic change. Hence HPV vaccination to be used in prevention of giant condyloma caused by HPV 6 or 11.
Biography
Uma Nahar Saikia has completed her MD, Pathology from NIMS, India and is currently working as a Professor at the Department of Histopathology, PGIMER, India.
She is a Member of International Medical sciences Academy (FIMSA), International Society for Dermatopathology (ISDP), Member of National Academy of Medical
Sciences (NAMS), Indian Society of Heart Research (ISHR), Dermatopathology Society of India (DSI), Indian association of Pathologists and Microbiologists
(IAPM). She has published more than 200 international and 49 national papers in reputed journals.
Uma Nahar Saikia et al., J Infect Dis Ther 2018, Volume 6
DOI: 10.4172/2332-0877-C7-056