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.com
Volume 08
Journal of Novel Physiotherapies
Rehabilitation Medicine 2018
May 18-19, 2018
May 18-19, 2018 Osaka, Japan
7
th
World Congress on
Physical Medicine and Rehabilitation
Effect of oropharyngeal rehabilitation training for obstructive sleep apnea on inflammation expression
of endothelial cell
Chih Ju Chang, Ching Hsia Hung and Hsin Yu Lin
National Cheng Kung University, Taiwan
Introduction:
Obstructive sleep apnea (OSA) is a prevalent sleep-related breathing disorder which might be caused by multiple
pathogeneses primarily including upper airway (UA) anatomic impairment, ventilatory drive instability and oropharyngeal
muscle dysfunction. However, the previous studies have demonstrated that most OSA population has been regarded as
collapsible UA with poor oropharyngeal function. OSA is defined by repetitive events of complete and partial obstructions
of the upper airway. The repetitive hypoxia and re-oxygenation increase the systemic inflammation and deteriorate the
oxidative stress. Recently, OSA has been proven high comorbidity with cardiovascular diseases which inflammatory processes
control the critical pathway. The prevalence of cardiovascular diseases among OSA compared to healthy population is higher.
Therefore, we propose a comprehensive oropharyngeal rehabilitation program with 12 weeks intervention may attenuate the
inflammation of OSA population.
Objectives:
The purpose of this study is to investigate the biological effect of rehabilitation training for obstructive sleep apnea
on the inflammatory expression of endothelial cells.
Methodology:
We use RCT with participant single blinded design to explore the different inflammatory expression between
pre and post intervention. The inflammation expression was used the flow cytometric analysis (FACScan) to detect the ICAM-
1 and VCAM-1 of the endothelial cell surface in response to patient’s serum.
Results:
In our study, we recruited 6 moderate to severe OSA patients and they have divided into intervention group and
control group. Patients in intervention group received rehabilitation training for 12 weeks and patients in control groups had
no treatment. The result of intervention group on the expression of ICAM and VCAM difference between pre- and post-
intervention were -2.57±1.7 and -4.75±8.6, respectively and that of control group were -0.37±1.6 in ICAM and 1.32±4.8 in
VCAM.
Conclusion:
The clinical implication of our finding is that rehabilitation training may attenuate the inflammation expression
of endothelial cell for OSA patients, which was caused by repetitive hypoxia and re-oxygenation.
Discussion:
There was no significant difference in inflammation expression between two groups, but the preliminary result
demonstrated that the expression of ICAM and VCAM decreased in the rehabilitation training intervention group.
Biography
Chih-Ju Chang is currently pursuing his Master’s degree in the Department of Physical Therapy in National Cheng Kung University, Taiwan. She is a Physical
Therapist with more than 3 years’ clinical experiences. Her research is to examine the biological effect of rehabilitation training to improve patients with obstructive
sleep apnea.
anne1990130@gmail.comChih Ju Chang et al., J Nov Physiother 2018, Volume 8
DOI: 10.4172/2165-7025-C2-027