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conferenceseries
.com
Volume 04
Journal of Clinical Infectious Diseases & Practice
ISSN: 2476-213X
Rare Diseases Congress 2019
June 17-18, 2019
June 17-18, 2019 | Berlin, Germany
9
th
World Congress on
Rare Diseases and Orphan Drugs
Change in gonadotropins in postmenopausal women: Effects of parity
Ekhator C N
1
, Egbon P O
2
, Ukponahiunsi C A
2
, Okoeguale V E
2
and
Koko K
1
1
Ambrose Alli University, Nigeria
2
St Philomena Catholic Hospital, Nigeria
Introduction:
This report assessed the effect of parity on gonadotropins pattern in postmenopausal women.
We studied 280 post menopausal women (40 each grouped into nulliparous to para 6). Although there was no
significant different in their ages, serum follicle stimulating hormone (FSH) and luteinizing hormone (LH) appeared
to correlate negatively with parity. Thus, the levels of gonadotropins may vary with parity in postmenopausal women.
Endocrinologically, female aging caused a progressive increase and decrease in FSH and estrogen levels respectively.
However, reports showed that FSH secretion varies with individual’s characteristics and only a few studies have
investigated the effect of age, body mass index, lifestyle factors and ethnic differences. This report was to assess the
effect of parity on gonadotropins changes in postmenopausal women.
Materials & Methods:
The study was conducted among 280 postmenopausal women attending clinic at Saint
Philomena Catholic Hospital in Benin City, Nigeria. They consisted of 40 subjects each with natural menopause
transition, devoid of medical, surgical or pathological influence and classified from nulliparous to para 6. After
inform consent and approval was given, medical history and blood sample were obtained for serum FSH and
luteinizing hormone levels.
Results:
The mean age of the women ranges from 56.05±6.91 to 59.25±5.45 years. Nulliparous postmenopausal
women had higher FSH (p>0.05) but lower LH (p<0.05) levels compared to porous postmenopausal women. Parity
seems to negatively correlate with FSH and LH levels in postmenopausal women.
Discussion:
Based on the results, serum gonadotropin levels may vary with parity as with age, BMI, lifestyle and
ethnicity.
Recent Publications
1. Burger H, Dudley E, Hopper J, Groome N, Guthrie J, Green A and Dennerstein L (1999) Prospectively measured
levels of serumfollicle-stimulating hormone, estradiol and the dimeric inhibins during themenopausal transition
in a population based cohort of women. J Clin Endocrinol Metab. 84(11):4025-4030.
Ekhator C N et al., J Clin Infect Dis Pract 2019, Volume 04
Values are mean ± SEM; * significant at p<0.05
Fig: FSH and LH levels at different parity
in postmenopausal women.