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conferenceseries
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Volume 7
OMICS Journal of Radiology
Radiology and Oncology 2018
July 16-17, 2018
July 16-17, 2018 Dubai, UAE
Radiology and Oncology
2
nd
World Congress on
Prognostic significance of magnetic resonance imaging in patients with severe nonpenetrating
traumatic brain injury requiring decompressive craniectomy
Ravi Ambati, Kwok M Ho and Stephen Honeybul
Royal Perth Hospital, Australia
Background:
Diffuse Axonal Injury (DAI) detected on Magnetic Resonance Imaging (MRI) may be useful to predict outcome
after Traumatic Brain Injury (TBI).
Aim & Method:
This study compared the ability of the International Mission for Prognosis and Analysis of Clinical Trials
(IMPACT) prognostic model with DAI on MRI to predict the 18-month neurologic outcome in 56 patients who had required
decompressive craniectomy after TBI.
Results:
Of the 56 patients included in the study (19 scans occurred within 14 days, median time for all patients 24 days,
interquartile range 14-42), 18 (32%) had evidence of DAI on the MRI scans. The presence of DAI on the MRI Diffusion-
Weighted (DW) T2*-weighted gradient echo and Susceptibility-Weighted (SWI) sequences was associated with an increased
risk of unfavorable outcome at 18months comparedwith patients without DAI (44%vs. 17%, difference = [ 27%, 95%confidence
interval 2.4-46.7% ; P = 0.032), particularly when the brainstem was involved. However, neither the grading (1 to 4) nor the
number of brain regions with DAI was as good as the IMPACT model in discriminating between patients with unfavorable and
favorable outcomes (area under the receiver operating characteristic curve: 0.625 and 0.621 vs. 0.918, respectively; P<0.001 for
both comparisons). After adjustment for the IMPACT prognostic risks, DAI in different brain regions and the grading of DAI
were also not independently associated with unfavorable outcome.
Conclusion:
The prognostic significance of DAI on MRI may, in part, be captured by the IMPACT prognostic model.
More research is needed before MRI should be routinely used to prognosticate the outcomes in patients with TBI requiring
decompressive craniectomy.
Biography
Ravi Ambati is a medical doctor at Department of General Surgery, Royal Perth Hospital, Australia.
kwok.ho@health.wa.gov.auRavi Ambati et al., OMICS J Radiol 2018, Volume 7
DOI: 10.4172/2167-7964-C1-021