psychiatry-neuro-2018-scientifictracks

19 / 22

Page 50
Notes:
conferenceseries.com
Volume 6 Journal of Child and Adolescent Behavior Psychiatry Neuro 2018
November 12-13, 2018
November 12-13, 2018 Dubai, UAE
30th International Conference on
&
Joint Meeting on
Psychiatry and Mental Health
25 th Cognitive Neuroscience Congress
Transgenerational effect of morphine administration in male rats on electrophysiological properties of Locus
coeruleus neurons of the offspring
Narges Pachenari
Tarbiat Modares University, Iran
The number of adolescents who use illicit drugs has increased dramatically. Adolescence is a critical period for brain
development and maturation. Studies have confirmed that environmental stimuli such as drugs and stress can make long
lasting changes not only in the same person but also in the next generation. Among transgenerational studies of substance
abuse, there is a lack of studies on the electrophysiological properties of different parts of the brain. Locus coeruleus is the main
noradrenergic nucleus in the brain and supply most of the noradrenalin of the prefrontal cortex, the area which is involved
in the cognitive control. So, in this study we aimed to investigate transgenerational effect of morphine administration during
adolescence on electrophysiological properties of the locus coeruleus neurons of the offspring. Male rats received escalating
doses of morphine for 10 days during their adolescence. 20 days after the last morphine injection, male rats were mated
with intact female rats and whole cell patch clamp recording was performed in the LC neurons of the offspring. The results
demonstrated that some electrophysiological properties of LC neurons of morphine sired animals have changed dramatically
compared to saline sired ones. These changes include half width, maximum decay slope and antipeak amplitude of the action
potentials. This data suggest that morphine administration lead to subtle alteration in the kinetic of some channels of the LC
neurons in the offspring which can affect noradrenalin release in other parts of the brain.
Biography
Narges Pachenari is a PhD student at Tarbiat Modares University. Her major is physiology and she is currently working on her thesis. Transgenrational effect of
morphine addiction on pain perception, morphien analgesia and electrophysiological properties of Locus coeruleus neurons is her main field of study. She is so
interested in cognitive science area and wants to continue her research in this field.
Narges Pachenari, J Child Adolesc Behav 2018, Volume 6
DOI: 10.4172/2375-4494-C2-008