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Page 43
Volume 08
Clinical Pharmacology & Biopharmaceutics
ISSN: 2167-065X
Pharmacology 2019
World Heart Congress 2019
August 19-20, 2019
JOINT EVENT
conferenceseries
.com
August 19-20, 2019 Vienna, Austria
&
7
th
World Heart Congress
24
th
World Congress on
Pharmacology
Prognostic value of speckle tracking echocardiography in peripartum cardiomyopathy patients: A long
term single center study
Doaa A Fouad, Hatem Abdel-Rahman Helmy, Safwat Abdelrady Salman, Hanan Galal Abdel-Azeem
and
Ahmed Mohammed Moheb El-Din
Assiut University, Egypt
P
atients who died had significantly impaired GLS and GCS vs. those improved (-9.07±0.65 vs.-16.09±2.57%,
-8.17±3.1 vs. -14.02±2.62 %, P<0.01)). More reduction was noted in apical GCS (-6.97±4.67 vs. -17.43±6.75%).
Patients with persistent LVdysfunction and those who diedwere presented later than improved (18±11.79 vs.7.5±4.93
days postpartum)
Conclusion & Significance
: Longitudinal and circumferential strains are depressed in PPCM patients. 2D-STE can
be used as an objective marker of LV dysfunction in PPCM patients at long term.
Recommendation
: A larger multicenter study is recommended. Meanwhile, STE is advised whenever PPCM is
suspected.
Statement of the Problem
: Although peripartum cardiomyopathy (PPCM) is a rare disease, its frequency is
higher in some regions including Egypt. It can result in morbidity and mortality of 5- 32%. Identifying prognostic
indicators of women with PPCM is of paramount importance. Speckle tracking echocardiography (STE) was found
helpful to assess early changes of left ventricular function and mechanics; however its prognostic value is still under
investigation.
Methodology & Theoretical Orientation
: This is a case-control prospective study that included 25 PPCM patients
admitted to the cardiology and woman health hospitals of Assiut University, Egypt from September 2016-December
2018 and 20 control pregnant women. Clinical assessment, 2-D echocardiography and STE were done to study
population upon inclusion, and at scheduled quarterly visits.
Findings
: Patients age was 29.9±7.68 years, 75% presented in the postpartum period. At presentation, LVEF was
impaired in patients vs. controls (33.2±8.84 % vs. 62.65±5.61 %, P<0.001), STE showed reduction of GLS (-10.08±6.76
vs.-19.49±2.82), GCS (-11.65±3.34 % vs.-23.63±2.93%) (P<0.001). Patients were followed-up for a median of 13.5
months where 9 improved (LVEF≥50%), 7 partially improved (LVEF=40-49%), 4 had persistent LV dysfunction
(LVEF<40%), 4 died. Along the study; GLS & GCS increased significantly (-13.03±4.53% to -20.18±1.75),
(-13.28±3.37% to -22.53±4.82%) in improved patients
Doaa A Fouad et al., Clin Pharmacol Biopharm, Volume 08