pediatrics-conference-2016_posters-accepted-abstracts

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Volume 6, Issue 4(Suppl) Pediat Therapeut 2016
ISSN: 2161-0665 Pediatrics, an open access journal
Page 72
Pediatrics Conference 2016
September 14-16, 2016
conferenceseries.com
7th European Pediatrics and
Pediatric Surgery
September 14-16, 2016 Amsterdam, Netherlands
Pediat Therapeut 2016, 6:4(Suppl)
Whole colon mobility with cecocolic volvulus and literature review
Biniam Ayele
Bahir Dar University, Ethiopia
Volvulus refers to torsion of a segment of the alimentary tract, which often leads to bowel obstruction. The most common sites of
volvulus are the sigmoid colon and caecum. Volvulus of other portions of the alimentary tract, such as the stomach, gallbladder,
small bowel, splenic flexure and transverse colon are rare. Patients with a caecal volvulus are young, with a mean age varying from
33 years in India to 53 years in Western countries. In contrast, sigmoid volvulus usually occurs in elderly subjects with chronic
constipation or distal colon obstruction. The common presentations are colicky abdominal pain, abdominal distention, constipation/
obstipation and depending on vascular status, the patient may be febrile and tachycardic. Here I present a case of cecocolic volvulus
involving cecum, ascending colon, transverse colon and distal ilium in a 13 years old girl after she presented with colicky abdominal
pain, distension, failure to pass feces and flatus for 3 days. She had also previous history of similar complaint but was self-limiting.
She was febrile and tachycardic. Diagnosis was made by plain abdominal x-ray which showed air fluid level. She was prepared and
operated and intraoperative finding was 360 degree clockwise rotated right colon and transverse colon along its mesentery which was
ischemic and the whole large bowel was mobile and redundant with its own long mesentery. We extended right hemicolectomy and
iliotransverse anastomosis. The patient was followed for 1 week in the ward and discharge improved. Now she is being followed in the
surgical referral clinic. Details of the pathology, diagnosis and management will be discussed.
Use of juvenile animal studies to support oncology medicine development in children
Dinah Duarte1,2
1INFARMED-Autoridade Nacional do Medicamento e Produtos de Saude, Portugal
2Lusofona University, Portugal
When planning the pediatric development of any pharmaceutical, aspects that need to be taken into consideration include the
understanding of potential for modified sensitivity vs. adults, unique toxicities or potential for effects on organ development.
The need for early consideration of children has led to an increased focus on the relevance of nonclinical studies in juvenile animals
(JAS). The immaturity of the developing organ may increase the potential for new target organs, modified activity or greater toxicity
than has previously been seen in adults. While needing to screen for potential safety concerns associated to medicines use in children,
avoiding useless studies and animal protection principles are strongly taken into consideration also. The need for animal studies for
oncology drugs is in general a matter of controversy in particular for the most severe forms and the experience for JAS in advanced
cancer patients is of importance. We intend to present a revision of results collected during the development of oncology pediatric
medicines, towards pediatric use and build up the experience on utility of JAS. Also, a critical analysis of nonclinical information on
all approved European Public Assessment Reports (EPARs: 1995– 2014) concerning existence of JAS, pediatric therapeutic indication,
and species and data from JAS in the nonclinical information on all approved pediatric investigation plans (PIPs) to support an
indication in pediatric population (2007-2014). Further emphasis is placed on nonclinical support where PIPs refers to neonates and
infants and the usefulness of such studies especially for tumors leading to short life expectancy.